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博士&硕士生导师
刘相国
作者:   时间:2017-12-12   点击数:

刘相国 教授 博士生导师  

    电话:0532-58630878

        E-mail: xgliu@sdu.edu.cn

教育经历

1990.9-1994.7 山东大学生物系  理学学士学位(生物学)

1994.9-1997.7太阳商城贵宾会2017Cm 理学硕士学位(细胞生物学)

1997.9-2000.7中国科学院微生物研究所 理学博士学位(微生物学)

工作经历

2000.9-2002.11,北京大学医学部基础医学院免疫系 博士后

2002.11-2003.8,美国University of Florida医学院 博士后

2003.9-2008.8,美国Emory大学Winship Cancer Institute 博士后

2008.10-现在, 太阳商城贵宾会2017Cm 教授,博导

研究方向

1. 肿瘤细胞凋亡和自噬的分子机制

2. 肿瘤细胞转移的分子机制

3. 抗肿瘤药物筛选及作用机制

代表性论文

1. Yao S, Shi F, Wang Y, Sun X, Sun W, Zhang Y, Liu X, Liu X*, Su L*. Angio-associated migratory cell protein interacts with epidermal growth factor receptor and enhances proliferation and drug resistance in human non-small cell lung cancer cells. Cell Signal. 2019;61: 10-19.

2. An W, Yao S, Sun X, Hou Z, Lin Y*, Su L*, Liu X*. Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis in human non-small cell lung cancer cells. J Exp Clin Cancer Res. 2019; 38(1):181.

3. Li M, An W, Xu L, Lin Y, Su L*, Liu X*. The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells. J Exp Clin Cancer Res. 2019; 38(1):64.

4. Zhang M#, Su L#, Xiao Z, Liu X, Liu X*. Methyl jasmonate induces apoptosis and pro-apoptotic autophagy via the ROS pathway in human non-small cell lung cancer. Am J Cancer Res. 2016, 6(2):187-99.

5. Li T, Su L, Lei Y, Liu X, Zhang Y, Liu X*. DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells. J Biol Chem. 2015; 290:11108-18.

6. Liu X, Su L*, Liu X*. Loss of CDH1 Up-regulates Epidermal Growth Factor Receptor via Phosphorylation of YBX1 in Non-small Cell Lung Cancer cells. FEBS Lett. 2013; 587:3995-4000.

7. Li T, Su L, Zhong N, Hao X, Zhong D, Singhal S, Liu X*. Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells. Autophagy. 2013; 9(7):1057-1068.

8. Xu L, Su L, Liu X*. PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4- ATF3/CHOP axis in Human Lung Cancer Cells. Mol Cancer Ther. 2012; 11(10):2174-82.

9. Liu G, Su L, Hao X, Zhong N, ZHong D, Singhal S, Liu X*. Salermide Upregulates Death Receptor 5 Expression through the ATF4-ATF3-CHOP Axis and Leads to Apoptosis in Human Cancer Cells. J. Cell. Mol. Med. 2012; 16(7):1618-28.

10. Su L, Liu G, Hao X, Zhong N, Zhong D, Liu X*, Singhal S. Death Receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells. Eur. J. Cancer. 2011; 47(16):2471-8.

11. Oh YT#, Liu X#, Yue P, Kang S, Chen J, Taunton J, Khuri FR, Sun SY.ERK/RSK signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1. J Biol Chem. 2010; 285(53): 41310-41319.

12. Liu X, Yue P, Chen S, Hu L, Lonial S, Khuri FR, Sun SY. The Proteasome Inhibitor PS-341 (Bortezomib) Up-Regulates DR5 Expression Leading to Induction of Apoptosis and Enhancement of TRAIL-Induced Apoptosis Despite Up-Regulation of c-FLIP and Survivin Expression in Human NSCLC Cells. Cancer Res. 2007; 67 (10):4981-8.

13. Liu X, Yue P, Schonthal AH, Khuri FR, Sun SY. Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. Cancer Res. 2006; 66(23):11115-9.

14. Liu X, Yue P, Khuri FR, Sun SY. Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity. Cancer Res. 2005; 65(20): 9169-75.

15. Jin F#, Liu X#, Zhou Z, Yue P, Lotan R, Khuri FR, Chung LW, Sun SY. Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Res. 2005; 65(14):6354-63.

16. Liu X, Yue P, Zhou Z, Khuri FR, Sun SY. Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004; 96(23): 1769-80.

17. Liu X, Yue P, Khuri FR, Sun SY. p53 upregulates death receptor 4 expression through an intronic p53 binding site. Cancer Res. 2004; 64(15): 5078-83.

荣誉和奖励

山东大学优秀毕业生,1994

山东大学985学术带头人,2008

教育部新世纪优秀人才基金,2009

山东省自然科学杰出青年基金,2010

 

 

 

 

 

 

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