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硕士生导师
张剑
作者:   时间:2020-04-21   点击数:


 

张剑

副教授,硕士生导师

E-Mailzhj8226@sdu.edu.cn

教育背景

博士 2005.92010.6 华中农业大学 动物遗传育种与繁殖

学士 1998.92002.6 华中农业大学 畜牧

工作经历

2020.9-至今,山东大学,生命科学学院,副教授

2012.6-2020.8 山东大学,生命科学学院,讲师

2010.6-2012.6,山东大学,生命科学学院,博士后

科研方向

1. 胚胎干细胞,基因打靶和转基因动物相关的研究

2. 人类疾病动物模型的制作及发育相关基因功能的研究

主持课题

12018.12.01-2021.12.31,精子成熟关键基因突变动物模型的构建与功能研究-3,国家重点研发计划

22017.08-2020.06LOXL3突变导致人Stickler综合征的分子机制研究,山东省自然科学基金面上项目

32017.01-2019.12,基于CRISPR-Cas9技术的人DFNB105耳聋疾病动物模型的制作及其分析研究,山东大学交叉学科培育项目

42013.12-2016.12TPRN基因在小鼠内耳中的功能研究,山东省自然科学基金青年项目

代表性论文

1Zongzhuang Wen(#), Haixia Zhu, Aizhen Zhang, Jing Lin, Guangkai Zhang, Dongyue Liu, Yu Xiao, Chao Ye, Daqing Sun(*), Bin Wu (*), Jian Zhang(*), Jiangang Gao(*)Cdc14a has a role in spermatogenesis, sperm maturation and male fertility, Experimental Cell Research, 2020, 395 (1): 112178.

2Hui Xiao(#), Ning Ding, Hang Liao, Zhigang Yao, Xiankui Cheng, Jian Zhang(*), Miaoqing Zhao(*), Prediction of relapse and prognosis by expression levels of long noncoding RNA PEG10 in glioma patients. Medicine, 2019, 98(45):e17583.

3Zongzhuang Wen(#), Haixia Zhu(#), Zhenzu Li(#), Sen Zhang, Aizhen Zhang, Tingting Zhang, Xiaolong Fu, Daqing Sun(*), Jian Zhang(*), Jiangang Gao(*)A knock-in mouse model of Pendred syndrome with Slc26a4 L236P mutationBiochemical and Biophysical Research Communications20195152):359-365.

4Men, Yuqin#; Zhang, Aizhen; Zhang, Liwen; Jin, Yecheng; Wang, Zhishuo; Zhao, Jing; Yu, Xiaolin; Zhang, Jian*; Gao, Jiangang*, Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice., Front Med, 201610(4), pp 481-489.

5Zhang, Jian#; Liu, Ziyi; Chang, Aoshuang; Fang, Jie; Men, Yuqin; Tian, Yong; Ouyang, Xiaomei; Yan, Denise; Zhang, Aizhen; Sun, Xiaoyang; Tang, Jie; Liu, Xuezhong*; Zuo, Jian*; Gao, Jiangang*, Abnormal mRNA splicing but normal auditory brainstem response (ABR) in mice with the prestin (SLC26A5) IVS2-2A > G mutation, Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis,2016, 790, pp 1-7.

6Zhang, Jian#; Liu, Ziyi; Zhang, Tingting; Lin, Zhuchun; Li, Zhenzu; Zhang, Aizhen; Sun, Xiaoyang; Gao, Jiangang*, Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice, Scientific Reports,2016, 6, pp 33856.

7Zong, Wen#; Jiang, Yan; Zhao, Jing*; Zhang, Jian*; Gao, Jian-Gang, Estradiol plays a role in regulating the expression of lysyl oxidase family genes in mouse urogenital tissues and human Ishikawa cells., J Zhejiang Univ Sci B, 2015, 16(10), pp 857-864.

8Zhang, Jian#; Yang, Rui; Liu, Ziyi; Hou, Congzhe; Zong, Wen; Zhang, Aizhen; Sun, Xiaoyang; Gao, Jiangang*, Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice., Human Molecular Genetics, 2015,24(21), pp 6174-6185.

9Zhang, Jian#; Zhao, Jing#; Jiang, Wen-jie; Shan, Xi-wei; Yang, Xiao-mei*; Gao, Jian-gang*, Conditional gene manipulation: Cre-ating a new biological era., J Zhejiang Univ Sci B, 13(7), 2012, pp 511-524.

10Men, Yuqin#; Zhang, Aizhen; Li, Haixiang; Zhang, Tingting; Jin, Yecheng; Li, Huashun; Zhang, Jian*; Gao, Jiangang*, LKB1 Is Required for the Development and Maintenance of Stereocilia in Inner Ear Hair Cells in Mice.,2015, PLos One, 10(8).

11张剑#; 杨晓梅(*; 高建刚(*, 小鼠基因敲除的研究进展, 山东大学学报(理学版), 2011(10), pp 183-196

专利

张剑(#); 高建刚; 侯丛哲; 杨瑞; 刘子熠,一种小鼠Loxl3基因条件性敲除的方法与应用, 2017.6.6-2037.6.5, 中国, 201510080652 .5.

 

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